Structure of PDB 7ore Chain A

Receptor sequence
>7oreA (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
VDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK
KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVY
LVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS
NIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN
VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT
VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID
PAKRISVDDALQHPYINVWYDPAEVEAPPLDEREHTIEEWKELIYKEVMN
SE
3D structure
PDB7ore Controlling the Covalent Reactivity of a Kinase Inhibitor with Light.
ChainA
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0EI A I70 A91 K93 L144 V145 M146 M149 D150 N152 C154 Q155 L206 I27 A48 K50 L101 V102 M103 M106 D107 N109 C111 Q112 L163
BS02 0EI A I70 V78 A91 K93 L144 V145 M146 M149 D150 A151 Q155 L206 I27 V35 A48 K50 L101 V102 M103 M106 D107 A108 Q112 L163
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ore, PDBe:7ore, PDBj:7ore
PDBsum7ore
PubMed34081840
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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