Structure of PDB 7or1 Chain A

Receptor sequence
>7or1A (length=596) Species: 9606 (Homo sapiens) [Search protein sequence]
KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDK
VVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDE
DGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVV
LTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHST
EDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIE
LLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAF
NSTGIINEEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQINYFMDISNV
LEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENC
GIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSII
QTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLL
IGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVY
PNKPKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETE
3D structure
PDB7or1 Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60
ChainA
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0IG A W711 F716 L850 F853 E854 Q979 W265 F270 L394 F397 E398 Q523
BS02 CA A E788 Q791 N805 E337 Q340 N349
BS03 IHP A K593 K1046 K147 K563
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0015267 channel activity
GO:0015278 intracellularly gated calcium channel activity
GO:0042802 identical protein binding
GO:0097604 temperature-gated cation channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0007166 cell surface receptor signaling pathway
GO:0009409 response to cold
GO:0009410 response to xenobiotic stimulus
GO:0014070 response to organic cyclic compound
GO:0019233 sensory perception of pain
GO:0019722 calcium-mediated signaling
GO:0042542 response to hydrogen peroxide
GO:0048265 response to pain
GO:0050955 thermoception
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0050968 detection of chemical stimulus involved in sensory perception of pain
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070301 cellular response to hydrogen peroxide
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032421 stereocilium bundle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7or1, PDBe:7or1, PDBj:7or1
PDBsum7or1
PubMed
UniProtO75762|TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (Gene Name=TRPA1)

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