Structure of PDB 7oqr Chain A

Receptor sequence
>7oqrA (length=274) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
GRKVTEAPPFDVNSLRRDIEEILSEDMSKGPLFVRLAWHEAGSWDCRKKD
GSPNSASMRFHPECSYAGNKGLDKGRNALESLKKKYPKISYADLWSFAAV
VSIEAMGGPEIPWRWGRVDAKDGSVCGPDGRLPDASRMQDHVRDVFSRLG
FNDEETVALIGAHTCGECHLENTGYVGPFTHDKYGFDNSFFTELFGNEWM
LNPNVKKMQFMDKTTNRLMMLPADVSILLDDKYRSIAKKYADDNDYFCNA
FSKAYQKLLEVGTTDLKSLPAESK
3D structure
PDB7oqr Crystal structure of Trypanosoma cruzi heme peroxidase and characterization of its substrate specificity and compound I intermediate.
ChainA
Resolution1.76 Å
3D
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Enzymatic activity
Enzyme Commision number 1.11.1.5: cytochrome-c peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A P85 R89 W92 P187 A189 L213 A216 H217 G220 E221 C222 H223 N226 T227 L275 Y309 P31 R35 W38 P133 A135 L159 A162 H163 G166 E167 C168 H169 N172 T173 L221 Y255
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0016688 L-ascorbate peroxidase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006979 response to oxidative stress
GO:0034599 cellular response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oqr, PDBe:7oqr, PDBj:7oqr
PDBsum7oqr
PubMed35772495
UniProtQ8I1N3

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