Structure of PDB 7oqi Chain A

Receptor sequence

>7oqiA (length=256) Species: 9606 (Homo sapiens)

ELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADAL
GPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVK
KQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSS
TGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEA
GGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEA
YLSRLG

3D structure

• PDB: 7oqi Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
• Chain: A
• Resolution: 1.15 Å

Enzymatic activity

• Enzyme Commision number: 2.4.2.10: orotate phosphoribosyltransferase.
  4.1.1.23: orotidine-5'-phosphate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	OMP	A	S257 D259 K281 H283 D312 K314 M371 S372 P417 Q430 Y432 G450 R451	S34 D36 K58 H60 D89 K91 M148 S149 P194 Q207 Y209 G227 R228
BS02	U	A	S257 D259 K281 H283 K314 M371 S372 P417 Q430 Y432 G450 R451	S34 D36 K58 H60 K91 M148 S149 P194 Q207 Y209 G227 R228
BS03	OMP	A	D317 I318	D94 I95
BS04	U	A	D317 I318 T321	D94 I95 T98

Gene Ontology

Molecular Function

• GO:0004590 orotidine-5'-phosphate decarboxylase activity

Biological Process

• GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
• GO:0044205 'de novo' UMP biosynthetic process

External links

• PDB: RCSB:7oqi, PDBe:7oqi, PDBj:7oqi
• PDBsum: 7oqi
• UniProt: P11172|UMPS_HUMAN Uridine 5'-monophosphate synthase (Gene Name=UMPS)