Structure of PDB 7opq Chain A

Receptor sequence
>7opqA (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
HMSFLTEEEQEAIMKVLQRDAALKRAEEDYDYLIKFLALGDSGVGKTSVL
YQYTDGKFNSKFITTVGIDFREKRVVYRASGPDGATGRGQRIHLQLWDTA
GLERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYSENP
DIVLCGNKSDLEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEM
LLDLIMKRMERC
3D structure
PDB7opq Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
ChainA
Resolution2.23 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 06D A M92 Y121 I180 M184 C187 M117 Y146 I205 M209 C212
BS02 GNP A S17 G18 G20 K21 T22 S23 F33 S35 F37 T40 N132 K133 D135 L136 S162 A163 S42 G43 G45 K46 T47 S48 F58 S60 F62 T65 N157 K158 D160 L161 S187 A188
BS03 MG A T22 T40 T47 T65
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0031267 small GTPase binding
Biological Process
GO:0006886 intracellular protein transport

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7opq, PDBe:7opq, PDBj:7opq
PDBsum7opq
PubMed35308027
UniProtP51159|RB27A_HUMAN Ras-related protein Rab-27A (Gene Name=RAB27A);
Q9HCH5

[Back to BioLiP]