Structure of PDB 7opl Chain A

Receptor sequence
>7oplA (length=1070) Species: 9606 (Homo sapiens) [Search protein sequence]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKGERNATCGRMICDVE
ISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEH
TWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLH
AFYENNYIVPDKQIFRKPQQGLVLDPKVGFYDKFILLLDFNSLYPSIIQE
FNICFTTVQRVIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNP
DLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMH
TKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL
EIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCD
LAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEIN
KALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNL
TASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIA
TWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTC
GTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRR
FIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDK
SLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNT
AEQFLSRSGYSEVNLSKLFA
3D structure
PDB7opl Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
ChainA
Resolution4.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1283 C1310 C1315 C897 C924 C929
BS02 ZN A C1348 C1353 C1371 C1374 C962 C967 C985 C988
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:1902975 mitotic DNA replication initiation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7opl, PDBe:7opl, PDBj:7opl
PDBsum7opl
PubMed34719824
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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