Structure of PDB 7opk Chain A

Receptor sequence
>7opkA (length=649) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
GIPAAFRWLSNKYPKIISPVVEERPIVMPDGTEIPVDATRPNPNGEEFDN
LYLDMNGIVHPCSHPEDKPAPKDEEEMMIEIFKYTDRIVKMVRPRKILMI
AVDGVAPRAKMNQQRSRRFRAAQEAKEKEEEKKKAFDSNSITPGTPFMDI
LAASLRYWCAYKLNTDPAWAKLKVIISDATVPGEGEHKIMEFIRSQRSSP
EHNPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFFQEKPFIWLHVSI
LREYLAAELEVPNLPFRWDLERAIDDWVFLCFFVGNDFLPHLPALEIREN
GIDTLTAIWKDNLPIMGGYLTKDGHVDLERAQYILNGLAKQEDAIFRRRR
EVEERREAVDTVRLWEEGYADRYYEQKFKVDPKDIEFRHKVGRAYAEGLA
WVLQYYYQGCPSWEWFYPYHYAPFAADFVDLAKMEIKFEKGRISRPFEQL
MSVLPAASRHAIPEVYHDLMTDPNSPIIDFYPEEFEIDLNGKKMAWQGVA
LLPFIEMPRLLAAMKEREHLLSEEDRARNEPGFDVLLISDAHPGLYEDIT
SHFYSKKQGAPKFKLNPRRSDGLAGKVEKIEGYVPHGSLVYPLARNSMPD
VDYDRSITVRYIMPSSAHQHKSMLLRGVKLPPPALSRSDIEIIRSKAKN
3D structure
PDB7opk Observation of conformational changes that underlie the catalytic cycle of Xrn2.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D104 E209 E211 D103 E184 E186
BS02 MG A E211 D239 D241 E186 D214 D216
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0004534 5'-3' RNA exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7opk, PDBe:7opk, PDBj:7opk
PDBsum7opk
PubMed36008487
UniProtG0S058

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