Structure of PDB 7oo7 Chain A

Receptor sequence
>7oo7A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHK
3D structure
PDB7oo7 Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 G15 K16 S17 A18 F28 V29 D30 N116 K117 D119 L120 S145 A146 K147 G14 G16 K17 S18 A19 F29 V30 D31 N117 K118 D120 L121 S146 A147 K148
BS02 VLE A C12 K16 A59 G60 Q61 E62 Y64 S65 R68 D69 M72 H95 Y96 Q99 C13 K17 A60 G61 Q62 E63 Y65 S66 R69 D70 M73 H96 Y97 Q100
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7oo7, PDBe:7oo7, PDBj:7oo7
PDBsum7oo7
PubMed35471939
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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