Structure of PDB 7onw Chain A

Receptor sequence
>7onwA (length=485) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LRVQQVSTSRGMITDRSGRPLAVSVPVKAIWADPKEVHDAGGISVGDRWK
ALANALNIPLDQLSARINANPKGRFIYLARQVNPDMADYIKKLKLPGIHL
REESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQAAHNLALS
IDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNN
LSGTPKEAMRNRTITDVFEPGSTVKPMVVMTALQRGVVRENSVLNTIPYR
INGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGL
GKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATI
GSYGIYRPLSITKVDPPVPGERVFPESIVRTVVHMMESVALPGGGGVKAA
IKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASQPRFALVVVINDP
QAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALTT
3D structure
PDB7onw Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VL5 A E304 G306 S307 V344 S359 F417 G418 Y419 T495 G496 T497 A498 K499 Y541 E219 G221 S222 V259 S274 F332 G333 Y334 T410 G411 T412 A413 K414 Y456
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Biological Process
GO:0000917 division septum assembly
GO:0006508 proteolysis
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0009410 response to xenobiotic stimulus
GO:0043093 FtsZ-dependent cytokinesis
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane
GO:0032153 cell division site
GO:1990586 divisome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7onw, PDBe:7onw, PDBj:7onw
PDBsum7onw
PubMed34356681
UniProtP0AD68|FTSI_ECOLI Peptidoglycan D,D-transpeptidase FtsI (Gene Name=ftsI)

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