Structure of PDB 7oma Chain A

Receptor sequence

>7omaA (length=629) Species: 83810 (Thosea asigna virus)

RLSLEAMLAERAMVARQDLAGLKRKLAGADRVLAPQSPEQCGRESAQAQA
RSVTSELKSAVKEAQGLEHQTLDFLEQLGEYPVCGILHGDHPVHPSGTHN
NNGKVSVKRQFAAGSDALTCAFRFEDSDLVRETALKTTYTDGTWAGFVQR
LKMQTTRKCVQEKVSRKLLKQLFPYDPQKLVDVSGELSELVLGIKTNAIA
SAGPPYWRTKRDALPDMLDCVLPLLYDHIVRKDLTTLRNKHPELFLAECK
NKTDRYEVESLGEKTRPYFSHPFHLSALVSVLSQSFSGALKIMTEDSTSF
NAYGFSWTNGGAEDLAIWARQAGEAGKKPPRIACYGDDTDIYYRKDGKLY
RICPDFKQMDGSVDATTIEAVVDYVVDAHVKQYPTARQFWEEVGKLWVEM
ATQSPFLIDGTKVYRKMQKDGLMTGVVGTTLFDTVKSALAYNDWADQLMF
GSLNLLEEKYAIEFFKNKHGLVIKEGTWKPALVNEDPGFGELWTEQKFLG
LQLKVVRRENEKVYVPNLPFEDWLTMWVTPRSETETMRERTLFDRARGLL
VTGAVFDERARGLMGAVINSTAPEVVCMRVQISDGYPSYDWVVSLYSRDH
PCDMPRVFPEAATLIASYRKQVMDTRVVI

3D structure

• PDB: 7oma Snapshots of a Non-Canonical RdRP in Action.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K266 R269 R280 Y349 D351 D352 T438 T443 D447 L513 M540 R545 D563 R564 G567 T571	K252 R255 R266 Y335 D337 D338 T424 T429 D433 L499 M526 R531 D544 R545 G548 T552
BS02	rna	A	Y153 A214 S215 K224 K264 K266 Y282 S294 Y317 G318 F319 S320 T322 Y349 G439	Y139 A200 S201 K210 K250 K252 Y268 S280 Y303 G304 F305 S306 T308 Y335 G425
BS03	POP	A	R280 Q372 M373	R266 Q358 M359
BS04	MG	A	D351 D369 F370	D337 D355 F356

External links

• PDB: RCSB:7oma, PDBe:7oma, PDBj:7oma
• PDBsum: 7oma
• PubMed: 34203380
• UniProt: Q6A562