Structure of PDB 7ol3 Chain A

Receptor sequence
>7ol3A (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]
KKAGPVQVLIVKDDHSFELDETALNRILLSEAVRDKEVVAVSVAGAFRKG
KSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEI
FLINKPDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLS
QNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGA
DGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATN
PNFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYF
KAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDK
PFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRNYLQQLESEIDEL
YIQYIKHNDSKNIFHAARAAAL
3D structure
PDB7ol3 A novel insertion mutation in atlastin 1 is associated with spastic quadriplegia, increased membrane tethering, and aberrant conformational switching.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A R77 K78 G79 K80 S81 F82 W112 R113 G114 R217 D218 P272 V276 R48 K49 G50 K51 S52 F53 W83 R84 G85 R188 D189 P243 V247
BS02 ALF A F76 R77 K80 R118 E119 T120 G149 F47 R48 K51 R89 E90 T91 G120
BS03 MG A S81 T120 S52 T91
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7ol3, PDBe:7ol3, PDBj:7ol3
PDBsum7ol3
PubMed34808209
UniProtQ8WXF7|ATLA1_HUMAN Atlastin-1 (Gene Name=ATL1)

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