Structure of PDB 7oih Chain A

Receptor sequence

>7oihA (length=573) Species: 9606 (Homo sapiens)

TCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTP
GVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDF
TPEPAARVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPG
SNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQD
NGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLR
EHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTA
MRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEP
NPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRER
LFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVL
RNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRK
LRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSN
SYPRDFVNCSTLPALNLASWREA

3D structure

• PDB: 7oih Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase.
• Chain: A
• Resolution: 2.603 Å

Enzymatic activity

• Enzyme Commision number: 1.11.2.2: myeloperoxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	A	F605 K671	F434 K500
BS02	CA	A	D262 T334 F336 D338 S340	D97 T163 F165 D167 S169
BS03	HEM	A	M253 G256 Q257 D260 D264 T266 E408 M409 R499 G501 H502 I505 L583 R590	M88 G91 Q92 D95 D99 T101 E237 M238 R328 G330 H331 I334 L412 R419
BS04	SCN	A	H261 R405 E408	H96 R234 E237
BS05	8PR	A	E268 P386 T404 V576	E103 P215 T233 V405

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:7oih, PDBe:7oih, PDBj:7oih
• PDBsum: 7oih
• PubMed: 36048150
• UniProt: P05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)