Structure of PDB 7oh7 Chain A

Receptor sequence
>7oh7A (length=1064) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
PRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFFL
CTSAIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNN
STAEIFSEAHDDFVEKRWIDIRVGDIIRVKSEEPIPADTIILSSSEPEGL
CYIETANLDGETNLKIKQSRVETAKFIDVKTLKNMNGKVVSEQPNSSLYT
YEGTMTLNDRQIPLSPDQMILRGATLRNTAWIFGLVIFTGHETKLLRNAT
ATPIKRTAVEKIINRQIIALFTVLIVLILISSIGNVIMSTADAKHLSYLY
LEGTNKAGLFFKDFLTFWILFSNLVPISLFVTVELIKYYQAFMIGSDLDL
YYEKTDTPTVVRTSSLVEELGQIEYIFSDKTGTLTRNIMEFKSCSIAGHC
YIDKIPEDKTATVEDGIEVGYRKFDDLKKKLNDPSDEDSPIINDFLTLLA
TCHTVIPEFQSDGSIKYQAASPDEGALVQGGADLGYKFIIRKPNSVTVLL
EETGEEKEYQLLNICEFNSTRKRMSAIFRFPDGSIKLFCKGADTVILERL
DDEANQYVEATMRHLEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAAT
TLDNRAEKLDEAANLIEKNLILIGATAIEDKLQDGVPETIHTLQEAGIKI
WVLTGDRQETAINIGMSCRLLSEDMNLLIINEETRDDTERNLLEKINALN
EHQLSTHDMNTLALVIDGKSLGFALEPELEDYLLTVAKLCKAVICCRVSP
LQKALVVKMVKRKSSSLLLAIGDGANDVSMIQAAHVGVGISGMEGMQAAR
SADIAVGQFKFLKKLLLVHGSWSYQRISVAILYSFYKNTALYMTQFWYVF
ANAFSGQSIMESWTMSFYNLFFTVWPPFVIGVFDQFVSSRLLERYPQLYK
LGQKGQFFSVYIFWGWIINGFFHSAIVFIGTILIYRYGFALNMHGELADH
WSWGVTVYTTSVIIVLGKAALVTNQWTKFTLIAIPGSLLFWLIFFPIYAS
IFPHANISREYYGVVKHTYGSGVFWLTLIVLPIFALVRDFLWKYYKRMYE
PETYHVIQEMQKYN
3D structure
PDB7oh7 Structural basis of substrate-independent phosphorylation in a P4-ATPase lipid flippase
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2Y5 A N1100 F1103 I1110 R1219 W1223 K1224 K1227 Y1235 H1236 N919 F922 I929 R1038 W1042 K1043 K1046 Y1054 H1055
BS02 ACP A T562 F698 K703 R704 K721 R755 T381 F517 K522 R523 K540 R574
BS03 MG A D560 T562 D954 D379 T381 D773
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140345 phosphatidylcholine flippase activity
GO:0140346 phosphatidylserine flippase activity
Biological Process
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0015914 phospholipid transport
GO:0032456 endocytic recycling
GO:0045332 phospholipid translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:1990530 Cdc50p-Drs2p complex
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oh7, PDBe:7oh7, PDBj:7oh7
PDBsum7oh7
PubMed34023399
UniProtP39524|ATC3_YEAST Phospholipid-transporting ATPase DRS2 (Gene Name=DRS2)

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