Structure of PDB 7ogj Chain A

Receptor sequence
>7ogjA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
RYPVKPEEMDWSELYPEFFAPQAQVEFADIGCGYGGLLVELSPLFPDTLI
LGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQ
LTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLEL
HDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFP
AIFRRIQDPV
3D structure
PDB7ogj Crystal structure of human METTL1 in complex with SAH
ChainA
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.33: tRNA (guanine(46)-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A G54 C55 G56 E77 I78 R79 S109 N110 A111 L130 F131 T208 E210 G31 C32 G33 E54 I55 R56 S86 N87 A88 L107 F108 T185 E187
Gene Ontology
Molecular Function
GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification

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Molecular Function
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Biological Process
External links
PDB RCSB:7ogj, PDBe:7ogj, PDBj:7ogj
PDBsum7ogj
PubMed
UniProtQ9UBP6|TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase (Gene Name=METTL1)

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