Structure of PDB 7ofv Chain A

Receptor sequence
>7ofvA (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMNEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNV
MEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLY
YYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGP
LSKKGFYLAFQDVGACIALVSVRVFYKKAPLTVR
3D structure
PDB7ofv NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
ChainA
Resolution1.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E55 M60 D61 E62 Q71 L105 I159 M164 C191 I192 A193 E30 M35 D36 E37 Q46 L80 I134 M139 C166 I167 A168
External links
PDB RCSB:7ofv, PDBe:7ofv, PDBj:7ofv
PDBsum7ofv
PubMed34293864
UniProtP54764|EPHA4_HUMAN Ephrin type-A receptor 4 (Gene Name=EPHA4)

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