Structure of PDB 7od1 Chain A

Receptor sequence
>7od1A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
EYQFTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSEILD
RYKSNSAQLLVEARVQPNPSHPPHHCAVCMQFVRKENLLSLACQHQFCRS
CWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRY
LFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQM
YHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHM
QCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALK
KYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNA
AKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVER
ADSYDRGDLENQMHIAEQRRRTLLKDFHDT
3D structure
PDB7od1 CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C297 C300 C315 C318 C234 C237 C252 C255
BS02 ZN A C323 C326 H333 C340 C260 C263 H270 C277
BS03 ZN A C233 C249 C252 C170 C186 C189
BS04 ZN A C257 C260 H265 C270 C194 C197 H202 C207
BS05 ZN A C139 C142 C161 C164 C76 C79 C98 C101
BS06 ZN A C156 H158 C183 C188 C93 H95 C120 C125
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048588 developmental cell growth
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071425 hematopoietic stem cell proliferation
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031466 Cul5-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7od1, PDBe:7od1, PDBj:7od1
PDBsum7od1
PubMed34518685
UniProtO95376|ARI2_HUMAN E3 ubiquitin-protein ligase ARIH2 (Gene Name=ARIH2)

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