Structure of PDB 7oc7 Chain A

Receptor sequence
>7oc7A (length=298) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
AEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNGSTNDSK
TTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFNLYRDWFGTSPLTHKL
YMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQN
SGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYM
DQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEV
FVDANRYYWTATSNYNSGACGVISSAQNRNYSAADVTRAFSTVGVTCP
3D structure
PDB7oc7 Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.26: pseudolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H140 H144 E164 H140 H144 E164
BS02 V85 A V137 H140 E141 L197 R198 H223 V137 H140 E141 L197 R198 H223
BS03 CA A D136 E172 E175 D183 L185 D136 E172 E175 D183 L185
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7oc7, PDBe:7oc7, PDBj:7oc7
PDBsum7oc7
PubMed34762767
UniProtP14756|ELAS_PSEAE Elastase (Gene Name=lasB)

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