Structure of PDB 7oai Chain A

Receptor sequence
>7oaiA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
DVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGL
STEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIV
KRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKEN
SAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWG
CGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVR
RMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRK
3D structure
PDB7oai Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 C146 G162 T182
Catalytic site (residue number reindexed from 1) D137 K139 C142 G158 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V5W A I18 A39 F93 M94 D95 G96 C146 L148 G161 G162 I14 A35 F89 M90 D91 G92 C142 L144 G157 G158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7oai, PDBe:7oai, PDBj:7oai
PDBsum7oai
PubMed34543009
UniProtO14936|CSKP_HUMAN Peripheral plasma membrane protein CASK (Gene Name=CASK)

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