Structure of PDB 7o70 Chain A

Receptor sequence
>7o70A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHK
3D structure
PDB7o70 Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
ChainA
Resolution1.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V4T A C12 K16 T58 A59 G60 Q61 E62 R68 M72 H95 Y96 Q99 V103 C13 K17 T59 A60 G61 Q62 E63 R69 M73 H96 Y97 Q100 V104
BS02 GDP A G13 V14 G15 K16 S17 A18 F28 V29 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 F29 V30 D31 N117 K118 D120 L121 S146 A147 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7o70, PDBe:7o70, PDBj:7o70
PDBsum7o70
PubMed35471939
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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