Structure of PDB 7o45 Chain A

Receptor sequence
>7o45A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
DQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFL
ELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTA
AEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDT
3D structure
PDB7o45 Structure of the DNMT3B ADD domain suggests the absence of a DNMT3A-like autoinhibitory mechanism.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C435 C438 C455 C458 C22 C25 C42 C45
BS02 ZN A C478 C481 C500 C503 C65 C68 C87 C90
BS03 ZN A C490 C495 C524 C527 C77 C82 C111 C114
External links
PDB RCSB:7o45, PDBe:7o45, PDBj:7o45
PDBsum7o45
PubMed35760008
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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