Structure of PDB 7o2i Chain A

Receptor sequence
>7o2iA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRL
NIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRII
RHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIE
RLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDG
3D structure
PDB7o2i Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.348: mRNA m(6)A methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V22 A D377 R379 D395 Y406 G407 T408 L409 E481 S511 H512 F534 R536 G548 N549 D10 R12 D28 Y39 G40 T41 L42 E109 S139 H140 F162 R164 G176 N177
Gene Ontology
Molecular Function
GO:0001734 mRNA m(6)A methyltransferase activity
Biological Process
GO:0001510 RNA methylation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o2i, PDBe:7o2i, PDBj:7o2i
PDBsum7o2i
PubMed33902106
UniProtQ86U44|MTA70_HUMAN N6-adenosine-methyltransferase catalytic subunit (Gene Name=METTL3)

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