Structure of PDB 7o22 Chain A

Receptor sequence

>7o22A (length=464) Species: 9606 (Homo sapiens)

QEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNH
PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGV
CGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDG
KTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTN
SIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAND
WATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKD
IGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMG
TRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNY
GTLTKFTLVLYGTA

3D structure

• PDB: 7o22 OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D174 D179 D181	D64 D69 D71
BS02	CA	A	D115 D162 V205 N208 V210 G212	D5 D52 V95 N98 V100 G102
BS03	CA	A	D258 D301 E331	D148 D191 E221
BS04	NA	A	T309 S311 T314 S316	T199 S201 T204 S206
BS05	UYW	A	H194 S253 W254 G255 D258 G294 N295 W328 Y329 T365 G366 S368	H84 S143 W144 G145 D148 G184 N185 W218 Y219 T255 G256 S258

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:7o22, PDBe:7o22, PDBj:7o22
• PDBsum: 7o22
• PubMed: 34415722
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)