Structure of PDB 7o20 Chain A

Receptor sequence

>7o20A (length=466) Species: 9606 (Homo sapiens)

YQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKN
HPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG
VCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDD
GKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT
NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQK
CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAN
DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPK
DIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPM
GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANN
YGTLTKFTLVLYGTAS

3D structure

• PDB: 7o20 OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UYT	A	E236 G255 D264 Y308	E127 G146 D155 Y199
BS02	UYT	A	S253 W254 G255 P256 E257 D258	S144 W145 G146 P147 E148 D149
BS03	UYT	A	P266 A267 R268	P157 A158 R159
BS04	CA	A	D174 D179 D181	D65 D70 D72
BS05	CA	A	D115 D162 V205 N208 V210 G212	D6 D53 V96 N99 V101 G103
BS06	CA	A	D258 D301 E331	D149 D192 E222
BS07	NA	A	T309 S311 T314 S316	T200 S202 T205 S207

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:7o20, PDBe:7o20, PDBj:7o20
• PDBsum: 7o20
• PubMed: 34415722
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)