Structure of PDB 7o1u Chain A

Receptor sequence
>7o1uA (length=472) Species: 9606 (Homo sapiens) [Search protein sequence]
YQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKN
HPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG
VCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDD
GKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT
NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQK
CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAN
DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPK
DIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPM
GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANN
YGTLTKFTLVLYGTASGSLVPR
3D structure
PDB7o1u OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.75: furin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UYN A L227 V231 S253 W254 G255 P256 L118 V122 S144 W145 G146 P147
BS02 CA A D174 D179 D181 D65 D70 D72
BS03 CA A D115 D162 V205 N208 V210 G212 D6 D53 V96 N99 V101 G103
BS04 CA A D258 D301 E331 D149 D192 E222
BS05 NA A T309 S311 T314 S316 T200 S202 T205 S207
BS06 NA A D264 G265 A267 D155 G156 A158
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7o1u, PDBe:7o1u, PDBj:7o1u
PDBsum7o1u
PubMed34415722
UniProtP09958|FURIN_HUMAN Furin (Gene Name=FURIN)

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