Structure of PDB 7o1b Chain A

Receptor sequence
>7o1bA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
GPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQE
QLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCL
SYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIR
QKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTI
YFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS
3D structure
PDB7o1b Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
ChainA
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.4.2.8: phosphomannomutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D12 D14 D209 D8 D10 D205
BS02 MG A F221 T222 D223 T226 F217 T218 D219 T222
BS03 G16 A R123 R134 R141 G175 G176 I178 D181 R119 R130 R137 G171 G172 I174 D177
Gene Ontology
Molecular Function
GO:0004615 phosphomannomutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006013 mannose metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0009298 GDP-mannose biosynthetic process
GO:0019309 mannose catabolic process
GO:0061728 GDP-mannose biosynthetic process from mannose
GO:0061729 GDP-mannose biosynthetic process from fructose-6-phosphate
GO:0141199 GDP-mannose biosynthetic process from glucose
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o1b, PDBe:7o1b, PDBj:7o1b
PDBsum7o1b
PubMed34859900
UniProtO15305|PMM2_HUMAN Phosphomannomutase 2 (Gene Name=PMM2)

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