Structure of PDB 7o0q Chain A

Receptor sequence
>7o0qA (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPPQWICCDIRYLDVSILGKFAVVMADPPWDIPYGTLTDDEMRRLNIPV
LQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIGHWL
NHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSP
GTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGII
3D structure
PDB7o0q Crystal structure of the human METTL3-METTL14 complex bound to Compound 12 (ADO_AD_066)
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.348: mRNA m(6)A methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UY2 A D377 I378 R379 D395 Y406 L409 W431 E481 S511 K513 F534 R536 G548 N549 D10 I11 R12 D28 Y35 L38 W60 E105 S135 K137 F158 R160 G172 N173
Gene Ontology
Molecular Function
GO:0001734 mRNA m(6)A methyltransferase activity
Biological Process
GO:0001510 RNA methylation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o0q, PDBe:7o0q, PDBj:7o0q
PDBsum7o0q
PubMed
UniProtQ86U44|MTA70_HUMAN N6-adenosine-methyltransferase catalytic subunit (Gene Name=METTL3)

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