Structure of PDB 7o0h Chain A

Receptor sequence

>7o0hA (length=566) Species: 2170205 (White-tufted-ear marmoset simian foamy virus)

PLLQLPVEVKKTELNGFWDTGAQITCIPEAFLKEEIPIGEAQIKTLHTKL
QSVYYLKFKVLGRKVEAEVTTSPFDYVIISPSDIPWYKPQPLELTVKLPV
QDFKKELINKANINNEEKKQLAKLLDKYDVLWQQWENQVGHRKIPPHNIA
TGTVAPRPQRQYHINTKAKPSIQQVIDDLLKQGVLIKQTSVMNTPIYPVP
KPDGKWRMVLDYRAVNKTVPLIGAQNQHSLGILTNLVRQKYKSTIDLSNG
FWAHPITKDSQWITAFTWEGKQHVWTRLPQGFLNSPALFTADVVDLLKNI
PGISVYVDDIYFSTETVSEHLKILEKVFKILLEAGYIVSLKKSALLRYEV
TFLGFSITQTGRGLTSEFKDKIQNITSPRTLKELQSILGLFNFARNFVPN
FSEIIKPLYSLISTAEGNNIKWTSEHTRYLEEIVSALNHAGNLEQRDNES
PLVVKLNASPKTGYIRYYNKGGQKPIAYASHVFTNTELKFTPLEKLLVTM
HKALIKAIDLALGQPIEVYSPIISMQKLQKTPLPERKALSTRWITWLSYL
EDPRITFYYDKTLPDL

3D structure

• PDB: 7o0h Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
• Chain: A
• Resolution: 3.09 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.26.4: ribonuclease H.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Y167 Y202 D216 N221 Q232 H233 S234 G286 L288 N397 R400 K411 Y414 I417 S418	Y162 Y197 D211 N216 Q227 H228 S229 G281 L283 N392 R395 K406 Y409 I412 S413
BS02	dna	A	Y311 D313 L358 G359 K376 Q390 S391 G394 L395 T491 R547	Y306 D308 L353 G354 K371 Q385 S386 G389 L390 T486 R542

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:7o0h, PDBe:7o0h, PDBj:7o0h
• PDBsum: 7o0h
• PubMed: 34232702
• UniProt: D5JWV1