Structure of PDB 7ny8 Chain A

Receptor sequence
>7ny8A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
HMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHK
3D structure
PDB7ny8 RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 D31 N117 K118 D120 L121 S146 A147 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ny8, PDBe:7ny8, PDBj:7ny8
PDBsum7ny8
PubMed34193876
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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