Structure of PDB 7nxu Chain A

Receptor sequence
>7nxuA (length=427) Species: 11084 (Tick-borne encephalitis virus) [Search protein sequence]
PQAVVGTGWTSKGQITVLDMHPGSGKTHRVLPELIRQCIDRRLRTLVLAP
TRVVLKEMERALNGKRVRFHSGAIVDVMCHATYVNRRLLGRQNWEVAIMD
EAHWTDPHSIAARGHLYTLAKENKCALVLMTATPPGKSEPFPESNGAITS
EERQIPDGEWRDGFDWITEYEGRTAWFVPSIAKGGAIARTLRQKGKSVIC
LNSKTFEKDYSRVRDEKPDFVVTTDISEMGANLDVSRVIDGRTNIKPEEV
DGKVELTGTRRVTTASAAQRRGRVGRQDGRTDEYIYSGQCDDDDSGLVQW
KEAQILLDNITPVATFYGPEQDKMPEVAGHFRLTEEKRKHFRHLLTHCDF
TPWLAWHVAANVSSVTDRSWTWEGPEANAVDEASGDLVTFRSPNGAERTL
RPVWKDARMFKEGRDIKEFVAYASGRR
3D structure
PDB7nxu Mechanistic insight into the RNA-stimulated ATPase activity of tick-borne encephalitis virus helicase.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A E291 G420 R463 R466 E101 G230 R273 R276
BS02 ADP A P201 G202 S203 G204 K205 T206 H207 R466 P22 G23 S24 G25 K26 T27 H28 R276
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7nxu, PDBe:7nxu, PDBj:7nxu
PDBsum7nxu
PubMed35987382
UniProtP14336|POLG_TBEVW Genome polyprotein

[Back to BioLiP]