Structure of PDB 7nxm Chain A

Receptor sequence
>7nxmA (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]
RAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLS
PQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYN
PTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGV
YYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARN
KNNACGIANLASFPKM
3D structure
PDB7nxm An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UUW A C22 G23 C25 G65 G66 A137 N161 C23 G24 C26 G66 G67 A138 N162
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7nxm, PDBe:7nxm, PDBj:7nxm
PDBsum7nxm
PubMed34473502
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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