Structure of PDB 7nxf Chain A

Receptor sequence
>7nxfA (length=829) Species: 5141 (Neurospora crassa) [Search protein sequence]
EATPGGGRVVPEDMLQTDTRVGLTSEEVVQRRRKYGLNQMKEEKENHFLK
FLGFFVGPIQFVMEGAAVLAAGLEDWVDFGVICGLLLLNAVVGFVQEFQA
GSIVDELKKTLALKAVVLRDGTLKEIEAPEVVPGDILQVEEGTIIPADGR
IVTDDAFLQVDQSALTGESLAVDKHKGDQVFASSAVKRGEAFVVITATGD
NTFGHFTEVLNGIGTILLILVIFTLLIVWVSSFYRSNPIVQILEFTLAIT
IIGVPVGLPAVVTTTMAVGAAYLAKKKAIVQKLSAIESLAGVEILCSDKT
GTLTKNKLSLHDPYTVAGVDPEDLMLTACLAASRKKKGIDAIDKAFLKSL
KYYPRAKSVLSKYKVLQFHPFDPVSKKVVAVVESPQGERITCVKGAPLFV
LKTVEEDHPIPEEVDQAYKNKVAEFATRGFRSLGVARKRGEGSWEILGIM
PCMDPPRHDTYKTVCEAKTLGLSIKMLTGDAVGIARETSRQLGLGTNIYN
AERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVA
MTGDGVNDAPSLKKADTGIAVEGSSDAARSAADIVFLAPGLGAIIDALKT
SRQIFHRMYAYVVYRIALSIHLEIFLGLWIAILNRSLNIELVVFIAIFAD
VATLAIAYDNAPYSQTPVKWNLPKLWGMSVLLGVVLAVGTWITVTTMYAQ
GENGGIVQNFGNMDEVLFLQISLTENWLIFITRANGPFWSSIPSWQLSGA
IFLVDILATCFTIWGWFEHSDTSIVAVVRIWIFSFGIFCIMGGVYYILQD
SPKGNQKQRSLEDFVVSLQRVSTQHEKSQ
3D structure
PDB7nxf Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.2.1: P-type H(+)-exporting transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T380 I422 F451 K456 V458 K474 A476 L513 G559 D560 T300 I342 F371 K376 V378 K394 A396 L433 G479 D480
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0008553 P-type proton-exporting transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 monoatomic cation transport
GO:0051453 regulation of intracellular pH
GO:0120029 proton export across plasma membrane
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nxf, PDBe:7nxf, PDBj:7nxf
PDBsum7nxf
PubMed34757782
UniProtP07038|PMA1_NEUCR Plasma membrane ATPase (Gene Name=pma-1)

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