Structure of PDB 7nxd Chain A

Receptor sequence
>7nxdA (length=905) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVL
QGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQW
FGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAP
CRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQI
AESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVA
GVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLD
DLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGR
FGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQ
VLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRP
IVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIG
FTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYL
RNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQI
LLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQNVGEGGAYEA
ELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGA
SLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQ
VTLNGVSKPEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLY
VTRVTGLNCTTNHPINPKGLEGPQILKCPEAECFRLRCELGPLHQQESQS
LQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVA
TAVQW
3D structure
PDB7nxd Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
ChainA
Resolution4.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E239 S241 D243 T245 D247 E239 S241 D243 T245 D247
BS02 CA A D293 N295 D297 L299 D301 D293 N295 D297 L299 D301
BS03 CA A D360 D362 D364 Y366 D368 D360 D362 D364 Y366 D368
BS04 CA A D424 D426 N428 Y430 D432 D424 D426 N428 Y430 D432
BS05 CA A C604 G605 D607 I609 E644 C604 G605 D607 I609 E644
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0038023 signaling receptor activity
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001525 angiogenesis
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007565 female pregnancy
GO:0007613 memory
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014850 response to muscle activity
GO:0023035 CD40 signaling pathway
GO:0030335 positive regulation of cell migration
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589 cell-substrate adhesion
GO:0033627 cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0035313 wound healing, spreading of epidermal cells
GO:0035987 endodermal cell differentiation
GO:0045765 regulation of angiogenesis
GO:0046718 symbiont entry into host cell
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0098609 cell-cell adhesion
GO:1903672 positive regulation of sprouting angiogenesis
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0001726 ruffle
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0031410 cytoplasmic vesicle
GO:0032587 ruffle membrane
GO:0034674 integrin alpha5-beta1 complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0070161 anchoring junction
GO:0071062 alphav-beta3 integrin-vitronectin complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nxd, PDBe:7nxd, PDBj:7nxd
PDBsum7nxd
PubMed33962943
UniProtP08648|ITA5_HUMAN Integrin alpha-5 (Gene Name=ITGA5)

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