Structure of PDB 7nx4 Chain A

Receptor sequence
>7nx4A (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWK
VPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQ
QGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYV
FKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAA
GGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGG
CSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHG
EVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSP
3D structure
PDB7nx4 Structural basis of cytokine-mediated activation of ALK family receptors.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D732 H983 D55 H306
External links
PDB RCSB:7nx4, PDBe:7nx4, PDBj:7nx4
PDBsum7nx4
PubMed34646012
UniProtQ9UM73|ALK_HUMAN ALK tyrosine kinase receptor (Gene Name=ALK)

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