Structure of PDB 7nut Chain A

Receptor sequence
>7nutA (length=401) Species: 9606 (Homo sapiens) [Search protein sequence]
GAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADER
RDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTS
FCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAH
PEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGI
CVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDR
LPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGR
HTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALE
AASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQAD
A
3D structure
PDB7nut GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
ChainA
Resolution1.898 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLP A A154 N235 A236 H272 D294 L328 S329 G330 A149 N230 A231 H267 D289 L323 S324 G325
BS02 ZN A E143 H211 H232 E138 H206 H227
BS03 GLP A H242 R243 H237 R238
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
GO:0047419 N-acetylgalactosamine-6-phosphate deacetylase activity
Biological Process
GO:0006040 amino sugar metabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006046 N-acetylglucosamine catabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0019262 N-acetylneuraminate catabolic process
GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nut, PDBe:7nut, PDBj:7nut
PDBsum7nut
PubMed35229715
UniProtQ9Y303|NAGA_HUMAN N-acetylglucosamine-6-phosphate deacetylase (Gene Name=AMDHD2)

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