Structure of PDB 7nub Chain A

Receptor sequence
>7nubA (length=773) Species: 485 (Neisseria gonorrhoeae) [Search protein sequence]
MQEHYQPAAIEPAAQKKWDDARISNVSEDASKPKYYCLSMFPYPSGKLHM
GHVRNYTIGDVLSRFKLLNGFNVMQPMGWDAFGMPAENAAMKNNVAPAAW
TYDNIEYMKTQLKSLGFAVDWEREVATCKPEYYRWEQWLFTKLFEKGIVY
RKNGTVNWDPVDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITDYAE
ELLNDLDKLEHWPEQVKTMQRNWIGKSRGMTVRFAVSDDSKQGLEGDYAK
FLQVYTTRPDTLMGATYVAVAAEHPLATAAAADKPELQAFIAECKEKKGV
PTGRYVVNPLNGDKLEVWIANYVLWGYGDGAVMAVPAHDERDFEFAAKYN
LPKKQVIAVGDNAFDANRWQEWYGDKENGVLVNSGDLDGLDFQTAFDAVA
AKLQSQGAGEPKTQYRLRDWGISRQRYWGCPIPIVHCEKCGNVPVPADQL
PVVLPENVVPDGMGSPLAKMPEFYETSCPCCGGAAKRETDTMDTFIESSW
YFFRYMSPKFSDGMVSAESAKYWGAVDQYIGGIEHAIGHLLYARFFTKLM
RDEGLVNVDEPFERLLTQGMVVCETYYRWINPADVVISGTEKMSKSKNNG
VDPQELINAYGADTARLFMMFAAPPEQSLEWSDSGVEGAHRFLRRLWRTV
YEYLKQGGAVKAFAGNQDGLSKELKDLRHKLHSTTAKVSDDYGRRQQFNT
AIAAVMELLNQYDKTDTGSEQGRAVAQEVLEAAVRLLWPIVPHICETLWS
ELNGAKLWEAGWPTVDEAALVKS
3D structure
PDB7nub Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip.
ChainA
Resolution3.02 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 USB A F41 P42 Y43 G51 H52 N55 D80 G544 E546 H547 H551 Q580 M582 V583 M635 F41 P42 Y43 G51 H52 N55 D80 G532 E534 H535 H539 Q568 M570 V571 M593
BS02 ZN A C449 C452 C490 C493 C437 C440 C478 C481
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7nub, PDBe:7nub, PDBj:7nub
PDBsum7nub
PubMed36038645
UniProtB4RNT1|SYL_NEIG2 Leucine--tRNA ligase (Gene Name=leuS)

[Back to BioLiP]