Structure of PDB 7ntr Chain A

Receptor sequence
>7ntrA (length=362) Species: 9606 (Homo sapiens) [Search protein sequence]
VGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKP
HIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMY
RSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEP
SLGVKKPTKALLFVLLSPVGPYFSFNPVSLWANPKYVRAWKGGTGDCKMG
GNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEE
ELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNR
VREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQY
GREERDWTIVLS
3D structure
PDB7ntr BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 HCI A F49 T260 G332 T333 A334 F28 T236 G308 T309 A310
BS02 PLP A R119 R212 K222 Y227 E257 T260 M261 L286 G288 V289 T290 G332 T333 R98 R188 K198 Y203 E233 T236 M237 L262 G264 V265 T266 G308 T309
BS03 HCI A Y90 V175 Y69 V154
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006629 lipid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7ntr, PDBe:7ntr, PDBj:7ntr
PDBsum7ntr
PubMed36261130
UniProtP54687|BCAT1_HUMAN Branched-chain-amino-acid aminotransferase, cytosolic (Gene Name=BCAT1)

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