Structure of PDB 7nro Chain A

Receptor sequence
>7nroA (length=202) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
PLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTN
CGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQ
PDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRND
PLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAG
KK
3D structure
PDB7nro Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UPW A M61 W69 Y76 L118 N120 Y122 L128 H131 D133 H187 I189 R204 N206 M48 W56 Y63 L105 N107 Y109 L115 H118 D120 H174 I176 R191 N193
BS02 MN A H131 D133 H187 H118 D120 H174
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0035515 oxidative RNA demethylase activity
GO:0035516 broad specificity oxidative DNA demethylase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair
GO:0035513 oxidative RNA demethylation
GO:0042245 RNA repair
GO:0070989 oxidative demethylation
GO:0072702 response to methyl methanesulfonate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nro, PDBe:7nro, PDBj:7nro
PDBsum7nro
PubMed34762429
UniProtP05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB (Gene Name=alkB)

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