Structure of PDB 7nrb Chain A

Receptor sequence
>7nrbA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
EPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKAR
QEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQE
RDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVL
KLTDFGFAKETEKYDKSCDMWSLGVIMYILLCGFPPFGFPNPEWSEVSED
AKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKD
HWDEVKEEMTSALATMRVDYDQV
3D structure
PDB7nrb Adaptive Cartesian and torsional restraints for interactive model rebuilding.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4O A L50 L52 G53 V58 K73 C120 M121 E122 L173 T186 D187 L18 L20 G21 V26 K41 C88 M89 E90 L140 T153 D154 BindingDB: IC50=210nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7nrb, PDBe:7nrb, PDBj:7nrb
PDBsum7nrb
PubMed33825704
UniProtQ16644|MAPK3_HUMAN MAP kinase-activated protein kinase 3 (Gene Name=MAPKAPK3)

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