Structure of PDB 7nl1 Chain A

Receptor sequence
>7nl1A (length=397) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence]
GVKAGDWLPGFTPREETVYVHGGVEPDPLTGAILPPIYQNTTFVQESVEN
YLSKGFSYSRTSNPTVLSLEKKIAEIEGGFGACCFATGMAATVTIFSAFL
APGDHCLVTNCSYGGTNRCARLHFSKYNIDFEFIDFRDPTNVEKAIRPQT
KVVFSESPCNPTLYLADIEAISQICKEKKVLHVCDSTFATPYMMRPLDLG
ADIVVQSTTKYYDGHNCTLGGAVISSTKEIHDKVFFLRNVMGNIMSAQTA
FYTLLTLKTLPIRVEKQSANAQKIAEFLSKHHKVEHVIYPGIPSFPQKEL
ALKQHKNVHGGMLAFEVKGGTEAGIRMMNHVPRPWSLCENLGACESIITC
PAVFTHANMLREDRLKVGITDGFIRVSVGIEDVNDLIDGLDYALSKA
3D structure
PDB7nl1 Structural basis of the inhibition of cystathionine gamma-lyase from Toxoplasma gondii by propargylglycine and cysteine.
ChainA
Resolution2.331 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.1.1: cystathionine gamma-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G108 M109 Y133 D205 S227 T229 K230 G88 M89 Y113 D185 S207 T209 K210
BS02 PLP A Y78 R80 Y58 R60
Gene Ontology
Molecular Function
GO:0004123 cystathionine gamma-lyase activity
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:7nl1, PDBe:7nl1, PDBj:7nl1
PDBsum7nl1
PubMed36883335
UniProtA0A125YN40

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