Structure of PDB 7ni9 Chain A

Receptor sequence
>7ni9A (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPPQWICCDIRYLDVSILGKFAVVMADPPWDIGTLTDDEMRRLNIPVLQ
DDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIGHWLNH
GKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGT
RKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISK
3D structure
PDB7ni9 Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.348: mRNA m(6)A methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UEW A C376 D377 I378 R379 D395 G407 L409 V432 T433 E481 S511 F534 G548 N549 Q550 C9 D10 I11 R12 D28 G34 L36 V59 T60 E103 S133 F156 G170 N171 Q172
Gene Ontology
Molecular Function
GO:0001734 mRNA m(6)A methyltransferase activity
Biological Process
GO:0001510 RNA methylation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ni9, PDBe:7ni9, PDBj:7ni9
PDBsum7ni9
PubMed
UniProtQ86U44|MTA70_HUMAN N6-adenosine-methyltransferase catalytic subunit (Gene Name=METTL3)

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