Structure of PDB 7ni7 Chain A

Receptor sequence
>7ni7A (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHLPYGTLTDDEMRRLNI
PVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIGH
WLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERL
SPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGII
SK
3D structure
PDB7ni7 Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.348: mRNA m(6)A methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UEH A D377 I378 R379 D395 Y406 G407 W431 E481 S511 K513 F534 R536 G548 N549 Q550 D10 I11 R12 D28 Y37 G38 W62 E107 S137 K139 F160 R162 G174 N175 Q176
Gene Ontology
Molecular Function
GO:0001734 mRNA m(6)A methyltransferase activity
Biological Process
GO:0001510 RNA methylation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ni7, PDBe:7ni7, PDBj:7ni7
PDBsum7ni7
PubMed
UniProtQ86U44|MTA70_HUMAN N6-adenosine-methyltransferase catalytic subunit (Gene Name=METTL3)

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