Structure of PDB 7ni1 Chain A

Receptor sequence
>7ni1A (length=104) Species: 9606 (Homo sapiens) [Search protein sequence]
CPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPG
VKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFT
PEPA
3D structure
PDB7ni1 Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.2.2: myeloperoxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A M87 G90 Q91 D94 D98 F99 T100 M87 G90 Q91 D94 D98 F99 T100
BS02 UEB A F99 E102 F99 E102
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:7ni1, PDBe:7ni1, PDBj:7ni1
PDBsum7ni1
PubMed36005476
UniProtP05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)

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