Structure of PDB 7nh7 Chain A

Receptor sequence
>7nh7A (length=295) Species: 31631 (Human coronavirus OC43) [Search protein sequence]
AASDWKPGYSMPVLYKYLNSPMERVSLWNYGKPVTLPTGCMMNVAKYTQL
CQYLNTTTLAVPVNMRVLHLGAGSEKGVAPGSAVLRQWLPAGTILVDNDL
YPFVSDSVATYFGDCITLPFDCQWDLIISDMYDPITKNIGEYNVSKDGFF
TYICHMIRDKLALGGSVAIKITEFSWNAELYKLMGYFAFWTVFCTNANAS
SSEGFLIGINYLCKPKVEIDGNVMHANYLFWRNSTVWNGGAYSLFDMAKF
PLKLAGTAVINLRADQINDMVYSLLEKGKLLIRDTNKEVFVGDSL
3D structure
PDB7nh7 OC43 coronavirus methyltransferase
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A N43 G71 G73 P80 D99 L100 C115 D130 M131 N43 G71 G73 P80 D99 L100 C115 D130 M131
Gene Ontology
Molecular Function
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7nh7, PDBe:7nh7, PDBj:7nh7
PDBsum7nh7
PubMed
UniProtP0C6X6|R1AB_CVHOC Replicase polyprotein 1ab (Gene Name=rep)

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