Structure of PDB 7nfb Chain A

Receptor sequence
>7nfbA (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADRELV
HMINWAKKVPGFVDLSLHDQVHLLESAWLEILMIGLVWRSMDHPGKLLFA
PDLLLDREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIILLN
SGVYTFSTLKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQRLAQL
LLILSHIRHMSNKGMEHLYSMKSKNVVPLSDLLLEMLDAHR
3D structure
PDB7nfb A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
ChainA
Resolution1.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 E380 E542 I53 K57 V71 E75 E235
BS02 GEN A M343 L346 E353 L387 M421 H524 L525 M38 L41 E48 L82 M116 H217 L218 BindingDB: IC50=395nM,EC50=240nM,Ki=370nM
External links
PDB RCSB:7nfb, PDBe:7nfb, PDBj:7nfb
PDBsum7nfb
PubMed34006920
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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