Structure of PDB 7neu Chain A

Receptor sequence
>7neuA (length=398) Species: 9606 (Homo sapiens) [Search protein sequence]
QSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVN
ASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQY
HSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGQTAKNAIW
IDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNV
DGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCS
ETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRS
KCKDHEELSLVASEAVRAIEKISKNIRYTYGQGSETLYLAPGGGDDWIYD
LGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
3D structure
PDB7neu Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa).
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H159 E162 R217 H288 E363
Catalytic site (residue number reindexed from 1) H156 E159 R214 H285 E360
Enzyme Commision number 3.4.17.20: carboxypeptidase U.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U9K A H159 R217 N234 R235 H288 S299 G336 Y341 D348 E363 H156 R214 N231 R232 H285 S296 G333 Y338 D345 E360
BS02 ZN A H159 E162 H288 H156 E159 H285
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0009410 response to xenobiotic stimulus
GO:0010757 negative regulation of plasminogen activation
GO:0030163 protein catabolic process
GO:0042730 fibrinolysis
GO:0051918 negative regulation of fibrinolysis
GO:0071333 cellular response to glucose stimulus
GO:0097421 liver regeneration
GO:2000346 negative regulation of hepatocyte proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7neu, PDBe:7neu, PDBj:7neu
PDBsum7neu
PubMed33764059
UniProtQ96IY4|CBPB2_HUMAN Carboxypeptidase B2 (Gene Name=CPB2)

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