Structure of PDB 7nel Chain A

Receptor sequence
>7nelA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADREL
VHMINWAKKVPGFVDLSLHDQVHLLESAWLEILMIGLVWRSMDHPGKLLF
APDLLLDREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIILL
NSGVYTFSTLKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKSKNVVPLSDLLLEMLDAHR
3D structure
PDB7nel A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 D538 L539 E542 I54 K58 L68 V72 E76 D232 L233 E236
BS02 EST A E353 F404 H524 L525 E49 F100 H218 L219 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:7nel, PDBe:7nel, PDBj:7nel
PDBsum7nel
PubMed34006920
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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