Structure of PDB 7ne6 Chain A

Receptor sequence

>7ne6A (length=418) Species: 9606 (Homo sapiens)

SCRCEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKE
GKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGI
PLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGASFS
FGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLMAPT
YKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLH
NMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQE
EKKRSGAIQVLSSFRRKVRMLAEPVKTCRGSDEVWSDSEQSFLDPDIGGV
AVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKH
GLALWEAKMAEKAREKEE

3D structure

• PDB: 7ne6 Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 1.14.11.80: methylcytosine dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R1261 R1262 S1286 S1290 M1293 Y1294 K1299 R1302 S1303 D1384 H1386 N1387 Y1902 H1904	R125 R126 S150 S154 M157 Y158 K163 R166 S167 D248 H250 N251 Y390 H392
BS02	dna	A	W1291 M1293 Y1294 N1296 K1905	W155 M157 Y158 N160 K393
BS03	ZN	A	C1193 C1271 C1273 H1380	C57 C135 C137 H244
BS04	ZN	A	C1133 C1135 H1219 C1221	C2 C4 H83 C85
BS05	ZN	A	C1289 C1298 C1358 H1912	C153 C162 C222 H400
BS06	MN	A	H1382 D1384 H1881	H246 D248 H369

Gene Ontology

Molecular Function

• GO:0070579 5-methylcytosine dioxygenase activity

Biological Process

• GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

External links

• PDB: RCSB:7ne6, PDBe:7ne6, PDBj:7ne6
• PDBsum: 7ne6
• PubMed: 36070377
• UniProt: Q6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)