Structure of PDB 7ne1 Chain A

Receptor sequence
>7ne1A (length=414) Species: 9606 (Homo sapiens) [Search protein sequence]
PDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEER
LRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLS
LGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNR
PHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPV
LQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKC
NGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANE
CVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGY
YRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRC
AKGYQQSRSPIAPC
3D structure
PDB7ne1 Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
ChainA
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GU4 A H92 K101 H55 K64
BS02 YYJ A S90 C91 H92 S53 C54 H55
BS03 CA A F107 D110 T118 S277 F70 D73 T81 S240
External links
PDB RCSB:7ne1, PDBe:7ne1, PDBj:7ne1
PDBsum7ne1
PubMed33740419
UniProtO95631|NET1_HUMAN Netrin-1 (Gene Name=NTN1)

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