Structure of PDB 7ndz Chain A

Receptor sequence
>7ndzA (length=216) Species: 2336 (Thermotoga maritima) [Search protein sequence]
HMKIDILDKGFVELVDVMGNDLSAVRAARVSFDDEERDRHLIEYLMKHGH
ETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSP
ERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLN
LYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFE
AFLKYAYKGDILKEVQ
3D structure
PDB7ndz An enzymatic activation of formaldehyde for nucleotide methylation.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HUF A R78 H79 R80 I81 N169 L173 R174 H178 R75 H76 R77 I78 N166 L170 R171 H175
BS02 HUF A T55 E58 I81 N163 R165 T52 E55 I78 N160 R162
BS03 HUF A N85 E86 S88 N82 E83 S85
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ndz, PDBe:7ndz, PDBj:7ndz
PDBsum7ndz
PubMed34315871
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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