Structure of PDB 7ndo Chain A

Receptor sequence
>7ndoA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
TADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADRELVHMINW
AKKVPGFVDLSRHDQVHLLESAWLEILMIGLVWRSMDHPGKLLFAPDLLL
DREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIILLNSGVYT
FKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKSKNVVPSYDLLLEMLDAH
3D structure
PDB7ndo A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAL A L346 D351 E353 I424 H524 N532 P535 L36 D41 E43 I114 H209 N217 P220 BindingDB: IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
External links
PDB RCSB:7ndo, PDBe:7ndo, PDBj:7ndo
PDBsum7ndo
PubMed34006920
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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